spindle cell cancer

The elderly are more at risk for developing this illness than those under the age of 40, but it is known to strike younger patients as well. Once the cancer has spread to other areas, symptoms can include fatigue, nausea, pain, and bruising. Spindle cell carcinomas occur at every head and neck subsite but have a predilection for the oral cavity and larynx. In the absence of the SCC component, diagnosis is more difficult because in these instances, one has to distinguish between the so-called monophasic SpCC and a possible medley of mesenchymal spindle cell lesions, either benign or malignant, such as various types of spindle cell sarcomas and nodular fasciitis.353. A spindle cell sarcoma is a soft tissue sarcoma whose cells exhibit a spindle shape, with an elongated body that is wider … In spindle cell tumors the important morphologic features to evaluate on hematoxylin and eosin–stained sections are similar to those for other mesenchymal neoplasms, including the following: Architectural arrangement of the tumor cells (growth pattern): long or short fascicles, whorls, sheets, or haphazard architecture, Interface between tumor and adjacent tissues: pushing/expansile or infiltrative borders, Amount and type of extracellular matrix: prominent, scant, or inconspicuous; collagenous, hyalinized, or myxoid, Intratumoral vascularity: well-developed or inconspicuous; muscular thick-walled or thin-walled vessels, hyalinized vessel walls, branching (hemangiopericytoma [HPC]-like) vessels, Cytomorphology: long or short spindle cells, uniformity or pleomorphism, amount and quality of the cytoplasm, nuclear features, degree of atypia. Spindle cell (sarcomatoid) carcinoma of the breast is a rare variant of breast cancer that has been classified under the broad rubric of metaplastic carcinoma. Spindle cell sarcoma is a soft-tissue tumour which can start in the bone. Spindle cell carcinomas are characterized by a proliferation of spindle cells with varying degrees of atypia and mitotic activity, often exhibiting transitions with areas displaying the features of conventional spindle cell thymoma (Fig. Spindle cell sarcoma is a type of cancer which occurs on the connective tissues of the body. It may quickly spread from one tissue system to another, making it harder to treat. Most cancers made up of spindle cells are called sarcomas. (A) Small islands and cords of squamous cell carcinoma and dense proliferation of neoplastic spindle cells. However, sarcomas in the head and neck area located at mucosal surfaces are extremely rare, and, when they do occur, an intervening fibrous layer usually separates the lesion from the overlying epithelium. However, when a SCC component cannot be demonstrated, the diagnosis is more difficult and SpCC must be distinguished from a number of benign and malignant processes, such as spindle cell sarcomas, nodular fasciitis, inflammatory myofibroblastic tumor and malignant melanoma. Because these tumors demonstrate prominent exophytic growth with less extension into the esophageal wall, they have been associated with relatively good survival rates. At other body sites, the label pseudoangiosarcomatous carcinoma has been used for lesions with this histomorphology.365 It must also be mentioned that conventional SCC sometimes contains myxoid areas with enlarged stromal cells exhibiting swollen vesicular nuclei, sometimes showing mitoses. There is often dense, desmoplastic fibrosis separating the bands of neoplastic cells into vague lobules and smooth-bordered islands. A diagnosis of a SpCC is based on demonstration of an invasive or in situ SCC and a malignant spindle cell component. Spindle Cell Carcinoma Spindle cell carcinoma (SpCC), also referred to as sarcomatoid carcinoma, is a biphasic tumor composed of conventional SCC and malignant spindle cells. Similar to conventional SCC, there is a strong association with a history of cigarette smoking. The growth pattern and cytomorphology are key features to help determine the line of differentiation of a spindle cell neoplasm. Spindle cell sarcomas of the bone are often found in the arms, legs and pelvis. In the case of SpCC, just as in conventional SCC, the tumor is either ulcerating or directly abutting onto the overlying epithelium without an intervening uninvolved stroma. Wikibuy Review: A Free Tool That Saves You Time and Money, 15 Creative Ways to Save Money That Actually Work. Moreover, the observation that stromal fibroblasts as well as endothelial cells may both show these atypical changes may be helpful in distinguishing between SpCC and SCC with atypical stromal features (Fig. The tumor can arise anywhere within the upper aerodigestive tract, with a predilection for the larynx and oral cavity. After surgery, chemotherapy and radiation are the most common treatment methods for spindle cell carcinoma. In a few reported cases of carcinosarcoma of the thymus, the spindle cell component has displayed features of rhabdomyoblastic differentiation by immunohistochemistry or electron microscopy.65 The majority of cases, however, are composed of poorly differentiated carcinomatous elements admixed with a poorly differentiated (vimentin-only) spindle cell sarcomatous component. Therefore, they have to be considered a variant of SCC in which the pleomorphic component originates through dedifferentiation of the SCC component.353–360 Molecular pathology has recently provided convincing proof of an evolution of the sarcomatoid component from the conventional one.360 Metastasis is to the cervical lymph nodes; the deposits may exhibit conventional SCC, SpCC, or both together.355,357,361,362, An SpCC typically occurs in the oral cavity and the larynx355,362; less frequently, it may arise in the sinonasal area and pharynx. Spindle cell carcinoma is a type of cancer which usually originates in the connective tissues of the body. Risk factors for spindle cell carcinoma of the upper aerodigestive tract include tobacco use, alcohol consumption, and previous radiotherapy. Sometimes, only spindle cells are present. The exact treatment options used and in what order will depend on the type of tissue being infected, as some respond better to radiation than chemotherapy. Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature. There is only one published work in the literature that studied HPV in these lesions. These data strongly argue that transcriptionally active HPV is rare in these tumors and, thus, not a significant contributor to their development or outcomes. Whether or not the entire mass can be removed will depend on where the tumor is located. The most sensitive/reliable epithelial marker for SpCC seems to be keratin (AE1/AE3, K1) K1, K18 and EMA. If such tumors are less cellular, they may mimic benign reactive lesions. Macroscopically, SpCC may be a polypoid tissue mass or a fungating or ulcerated lesion not different from conventional SCC (Fig. Spindle cell carcinoma is a relatively rare form of cancer. The characteristic spindle cell phenotype of the neoplastic cells in SpCC is the result of epithelial-mesenchymal transition. A： Spindle cell carcinoma is a kind of connective tissue cancer where the cells are spindle-shaped. Stage 1 – The lump is self-contained. An SpCC should not be confused with the so-called teratocarcinosarcoma.368,369 This neoplasm typically occurs in the nasal cavity and the paranasal sinuses, sites at which SpCC rarely occurs, and is characterized by an extremely diverse histologic pattern with mature and immature glands, benign squamous and malignant poorly differentiated epithelia, and rhabdomyosarcomatous, chondrosarcomatous, and neuroepithelial differentiation (Fig. Although this tumor is considered by some authors to be part of the spectrum exhibited by SpCC,353 its far more complex histology and different predilection site make its classification as a distinct entity separate from SpCC more appropriate. Occasionally, the spindle cells of the tumor may “stream off”or drop off from the overlying squamous epithelium. CASTLE: Similar to thymic carcinoma, the tumor is arranged in solid nests or lobules with an expansive or infiltrative growth of epithelioid cells into the surrounding thyroid parenchyma (Figure 24-88) or adjacent soft tissue and organs (larynx, trachea). Molecular pathology and genetics of SpCC is complex and is similar to poorly differentiated SCC. 2-33). Spindle cell carcinoma of the breast is a rare sub-type of breast cancer, that falls within the general category of metaplastic breast carcinoma. Treatment of SpCC is the same as for conventional SCC. Spindle cell carcinoma is an unusual variant of SCC where part, or all, of the tumor resembles a sarcoma (Figure 28). In the larynx, true sarcomas (with the exception of chondrosarcoma) and benign mesenchymal tumors are very rare. Key features assisting in differentiating SpCC from the inflammatory myofibroblastic tumor are the absence of dysplastic or carcinomatous epithelial components, lack of dropping off from the overlying squamous epithelium, and no atypical mitotic figures.367, Sometimes, UADT mucosal melanomas may present as polypoid masses composed of pleomorphic spindle cells. 2-29).359, Histologically, SpCC typically exhibits areas of SCC and areas of pleomorphic spindle cells. It is a special type of squamous cell carcinoma of skin Prolonged exposure to the sun’s ultraviolet rays may result in damage of skin DNA, causing the condition. The differential diagnosis of spindle cell lymphoma of the uterine cervix includes chronic cervicitis, soft tissue sarcoma, spindle cell carcinoma, spindle cell melanoma and dendritic cell tumour. Often the overlying epithelium may be ulcerated, and, because of this, the squamous component may not be seen; rarely, the tumor may be composed entirely of a spindle cell proliferation. Certain activities or behaviors may make you more prone to spindle cell carcinoma. Within the oral cavity, frequently involved sites include the tongue, gingiva/alveolar mucosa, buccal mucosa, floor of the mouth, and lip. Mitoses and necrosis are rare. It is more common in areas that have been exposed to the sun, although this is not always the case. In some studies, 50% to 60% of affected patients are alive after 5 years.1, Adrián Mariño-Enríquez MD, PhD, Jason L. Hornick MD, PhD, in Practical Soft Tissue Pathology: a Diagnostic Approach (Second Edition), 2019. These are often of connective tissue, such as bones (osteosarcoma), ligaments, blood vessels, and muscle (tumors of the heart). From: Modern Surgical Pathology (Second Edition), 2009, Nina Zidar, Nina Gale, in Encyclopedia of Cancer (Third Edition), 2019. When SCC and spindle cells are both observed, the diagnosis of SpCC is easily made. De très nombreux exemples de phrases traduites contenant "spindle cell" – Dictionnaire français-anglais et moteur de recherche de traductions françaises. Sun exposure should be limited during the brightest period the day, which is generally between 11 in the morning and three in the afternoon. Sarcomas are tumors that arise in the soft, connective tissues that support and surround the organs and other structures of the body. The patient may complain of swelling, pain, paresthesia, persistent ulceration, or bleeding. 16-4).21 In addition, most cases show squamous dysplasia in the overlying, or adjacent, mucosa, but this finding can be focal, and, thus, difficult to detect if only a limited number of tissue sections have been obtained. The World Health Organization (WHO) recognizes SpCC as a variant of SCC, and includes the term sarcomatoid squamous cell carcinoma . McDowell's Herbal Spindle Cell Cancer Support Mix can be used in conjunction with other alternative medicines or with orthodox medical treatments such as surgery, radiation and chemotherapy. J.S. Spindle cell carcinoma exhibits a predilection for older adult males, with a peak in the fifth and sixth decades. When occurring in the larynx, the differential diagnosis of SpCC also includes the recently recognized benign proliferative lesion that has been labeled inflammatory myofibroblastic tumor. After radiation exposure, bizarre granulation tissue–containing pleomorphic spindle cells and atypical mitotic figures may develop that should not be misinterpreted as tumor recurrences displaying the histomorphology of SpCC277; this was discussed previously in the section on laryngeal SCC. Because the term "metaplastic carcinoma" comprises a heterogeneous group of tumors, it has been difficult to reliably predict biologic potential or to determine optimal therapy. The name of these often ends in “sarcoma.” Foci of osteosarcomatous, chondrosarcomatous or rhabdosarcomatous differentiation may be present, particularly in patients who had previously been treated by radiotherapy (Fig. 8). It starts with just a small lump and inflammation and then the symptoms slowly progress as the cancer grows from one stage to another. One of the main symptoms of the disease is a mass or tumor on the skin, sometimes resembling an ulcer or sore. Polypoid glottic tumors appeared to have the most favorable prognosis (90% 3-year survival rate), whereas patients with supraglottic, hypopharyngeal, sinonasal, and oral SpCCs did poorly regardless of their tumor's gross appearance. The carcinomatous component is usually squamous, but rarely, it can be composed of adenocarcinomatous elements as well (Fig. Concerning age and sex, no differences between SpCC and conventional SCC have been reported. However, if SpCC occurs intraosseously,366 its distinction from sarcomas with a spindle cell appearance may be extremely difficult or even impossible if immunohistochemistry or electron microscopy fail to reveal epithelial characteristics (Fig. SpCC also shows features of epithelial-mesenchymal transition, e.g., up-regulation of transcription repressors (Snail, Slug, SIP and Twist etc.) The cells are arranged in short, reticulated, intersecting and streaming fascicles or bundles. When cells from this type of cancer are viewed under a microscope, they appear spindle-shaped. The characteristic spindle cell phenotype of the neoplastic cells in SpCC is the result of epithelial-mesenchymal transition. They most commonly arise in patients over the age of 40 and are extremely rare - making up just 2-5% of all primary bone cancer cases. It is a very aggressive form of cancer, and patients who are diagnosed generally do not live more than five years. Most of these tumors are associated with exposure to tobacco and alcohol, and as many as 15–20% are thought to be secondary to radiation exposure for some other cancers. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. URL: https://www.sciencedirect.com/science/article/pii/B9780128012383650924, URL: https://www.sciencedirect.com/science/article/pii/B9780323552257000105, URL: https://www.sciencedirect.com/science/article/pii/B9780123864567040016, URL: https://www.sciencedirect.com/science/article/pii/B9781416039662000175, URL: https://www.sciencedirect.com/science/article/pii/B9781416025894000024, URL: https://www.sciencedirect.com/science/article/pii/B9781416040590500199, URL: https://www.sciencedirect.com/science/article/pii/B978032349714500003X, URL: https://www.sciencedirect.com/science/article/pii/B9780323547239000099, URL: https://www.sciencedirect.com/science/article/pii/B9781437726077000336, Modern Surgical Pathology (Second Edition), 2009, Brad W. Neville DDS, ... Angela C. Chi DMD, in, Color Atlas of Oral and Maxillofacial Diseases, Human Papillomavirus and Epstein–Barr Virus in Head and Neck Lesions, Modern Surgical Pathology (Second Edition), Squamous Cell Carcinoma of the Upper Aerodigestive System, Diagnostic Surgical Pathology of the Head and Neck (Second Edition), Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas (Second Edition), Adrián Mariño-Enríquez MD, PhD, Jason L. Hornick MD, PhD, in, Practical Soft Tissue Pathology: a Diagnostic Approach (Second Edition), Endoscopic Ultrasonography in the Evaluation of Posterior Mediastinal Lesions. Spindle cell sarcoma occurs more often in men than it does in women, and it is known to most commonly affect individuals past their fourth decade of life. Sometimes SpCC exhibits acantholysis; in this way, spaces lined by pleomorphic cells are formed that may mimic angiosarcoma (Fig. (b) Higher-power view of the spindle cell (sarcomatoid) component showing poorly formed fascicles of pleomorphic malignant spindle cells (20 ×). Very rare RMS with epithelioid and spindle cell morphology, female predominance, marked osseous predilection, ALK expression, EWSR1/FUS-TFCP2 gene fusions, and highly aggressive clinical behavior have recently been recognized with only 23 cases reported in the English language literature. The name “spindle cell” comes from the shape the cells appear to have when viewed through a microscope. Pulmonary Spindle Cell Carcinoma is classified as a sarcomatoid carcinoma of lung, which are aggressive tumors, along-with pleomorphic carcinoma, giant cell carcinoma, carcinosarcoma, and pulmonary blastoma; Spindle Cell Carcinoma of Lung is a type of sarcomatoid carcinoma that can develop anywhere in the lung. Although reported survival rates vary, one recent study based on epidemiologic data from the United States reported 5-year disease-specific survival of 39% for spindle cell carcinoma of the oral cavity. The elongated nuclei have a syncytial pattern with delicate nuclear chromatin and small nucleoli (Figure 24-87) The epithelial cells are more polygonal and are arranged in glands, tubules, trabeculae, cords, papillae, glomeruloid structures, and sheets (Figure 24-87). The 31 cases of spindle cell carcinoma were tested for p16 immunohistochemistry and either RNA in situ hybridization or RT-PCR for high-risk HPV. These demographics do not suggest a relationship with HPV, but do not exclude it. It is important to discover spindle call sarcoma in the first stage as it can easily be treated … Spindle cells always express vimentin and often other mesenchymal filaments, such as myogenic markers (smooth muscle actin, muscle specific actin, desmin). Vascular invasion may be seen. Both were T4 tumors and had poor outcomes. There is no definite known cause for this type of tumour, but it can sometimes occur as … This type of carcinoma can cause a large mass, or tumor, which is generally surgically removed during the initial stages of treatment. The cells show mild to moderate nuclear pleomorphism, with large, round to oval nuclei with pale to vesicular-appearing chromatin, distinct but small nucleoli, and abundant eosinophilic cytoplasm with indistinct cell borders (syncytial arrangement; Figure 24-89). In a clinicopathologic review of 78 cases of pleomorphic carcinoma of the lung, 18% of patients had incidental findings on chest X-ray and spindle cell carcinoma was most frequently associated with giant cell carcinoma [1] . Therefore, in these cases, a diagnosis of SpCC does not apply. Currently, there is ample evidence that SCC cells can exhibit differentiation toward cells with a mesenchymal phenotype. 2-34). As a result, they are usually treated differently from small round cell sarcomas, and have different biological characteristics than those tumors and sarcomas with epithelioid morphology. The type of tumour depends on the location in the body and the way the cells look when examined under the microscope. spindle cell carcinoma A carcinoma—often squamous cell—which can occur on any epithelial surface (e.g., oral, anorectal, bladder, etc). Calcifications can be seen in the stroma. The converse situation, granulation tissue mimicking SpCC, may occur after ionizing-radiation exposure. Batsakis and colleagues370 reviewed the lethality of SpCC in the head and neck and correlated their findings by anatomic site. Smoking or chewing tobacco, sun exposure, alcohol use, and exposure to certain chemicals may raise the risk of developing this and other types of cancer. Therefore, discerning this lesion from SpCC should not be too problematic. Typically, spindle cell carcinoma can occur in any connective tissue in the body, although it is more common in some areas than others. Infiltrative borders, tumor necrosis, atypical or hyperchromatic nuclei, and mitotic activity may or may not be indicative of malignancy, and they should be interpreted according to the line of differentiation and other features of the lesion. Only two cases had detectable HPV RNA, only one of which was strongly p16-positive. There is a component of SCC in situ at the base of the polypoid mass (arrow) confirming this to be a carcinoma and not a true sarcoma (2 ×). The dual-positive case was from the larynx, and the other HPV RNA-positive case was from the oral cavity. Any large mass, ulcer, sore, or discolored areas of skin should be checked by a trained medical professional. Sometimes, abrupt keratinization may be seen. Spindle cell carcinoma. The only known cause of … {"}Spindle cell{"} is a descriptive phrase that denotes the cellular shape of many of the sarcomas encountered in the adult population. This Spindle Cell Cancer Support Mix, is given in conjunction with a powerful antioxidant extract derived from the bark of the Maritime Pine Tree, (Maritime Pine Bark Extract). Sclerotic fibrosis abruptly separates the spindle cell component into a lobular pattern. Spindle cell sarcoma is a rare malignant (cancerous) tumour which can develop in the bone or soft tissue. Eating a healthy diet and maintaining a proper weight and activity level may help to reduce the risk of spindle cell carcinoma along with other diseases. Lester D.R. Brad W. Neville DDS, ... Angela C. Chi DMD, in Color Atlas of Oral and Maxillofacial Diseases, 2019. The former component may be very scant or limited to noninvasive areas of epithelial dysplasia or carcinoma in situ located at the surface of the tumor, and its identification may require extensive sampling for histologic examination. In fact, many previously reported presumed primary soft tissue sarcomas of the esophagus, in retrospect, probably represent spindle cell carcinomas with a predominant undifferentiated soft tissue sarcoma component. Introduction Spindle cell carcinoma (SpCC) is a rare type of squamous cell carcinoma (SCC) consisting of poorly differentiated elongated epithelial cells that show sarcoma-like proliferation 1 . Spindle cell carcinoma generally exhibits a worse prognosis than conventional squamous cell carcinoma. Recently, p63 has been reported as a useful marker for SpCC.364, As SpCCs may, in their spindle cell component, exhibit not only vimentin expression but also other mesenchymal filaments, especially myogenic markers, positivity for this marker does not rule out a diagnosis of SpCC.359 Even the absence of keratin positivity cannot be considered evidence against a diagnosis of SpCC, as this may be due to loss of reactivity for antikeratin antibodies due to fixation or embedding procedures or to a phenotypic change of the tumor cells. This latter feature may be helpful in making the appropriate diagnosis. 2-31). Copyright © 2020 Elsevier B.V. or its licensors or contributors. De très nombreux exemples de phrases traduites contenant "spindle cell carcinoma" – Dictionnaire français-anglais et moteur de recherche de traductions françaises. Some tumours are made up almost entirely of spindle cells. Treatment: Surgery is the best way to eliminate the cancer. This discussion on SpCC and its differential diagnosis is finalized by remarking that SpCC sometimes may assume the appearance of an innocuous granulation tissue polyp. Microscopically, the SCC component may be well-, moderately- or poorly differentiated, keratinizing or nonkeratinizing, and transition between the two components may be abrupt or gradual. (B) Apico-basal orientation. LewisJr., R.D. Wilson T. Kwong, Thomas J. Savides, in Endosonography (Fourth Edition), 2019. Nodular fasciitis may exhibit mitotic figures, but they are not atypical; moreover, no cellular pleomorphism is present. 2-35). There are really no clinical symptoms that would distinguish this particular cancer from other types of breast cancers. Spindle cell carcinoma (SpCC), also referred to as sarcomatoid carcinoma, is a biphasic tumor composed of conventional SCC and malignant spindle cells. It is important to note the often abrupt transition between the two components of this tumor. Immunohistochemically, tumor cells in SpCC often express epithelial and mesenchymal markers. They are found both in normal, healthy tissue and in tumors. The most sensitive and reliable epithelial markers to be used for demonstration of the epithelial phenotype are keratin (AE1/AE3), K1, K18, and epithelial membrane antigen.359 Moreover, double-labeling has indicated keratin and vimentin in individual spindle cells,356 thereby illustrating the versatility of the intermediate filament phenotype. The cells are spindled, simulate a sarcoma (but stain for cytokeratin), and usually are more aggressive than non-spindle cell carcinomas. By continuing you agree to the use of cookies. However, spindle cell tumors can appear on the skin of a dog or cat as well, and be rather frustrating. 17-23).62 The neoplastic cells in these tumors represent spindled (sarcomatoid) epithelial cells by immunohistochemical markers, unlike thymic carcinosarcoma, in which a combination of true sarcomatous and carcinomatous elements is seen.20,21,65 The diagnosis of carcinosarcoma requires the demonstration of a true sarcomatous component admixed with the malignant epithelial elements. Together the two support mixes have the potential to slow the growth of the cancer and boost overall health. Distinguishing between monophasic SpCC and spindle cell sarcomas such as fibrosarcoma and leiomyosarcoma may be more difficult. The most common type of normal spindle cell is called a fibroblast. Spindle cell carcinoma. Batsakis and colleagues370 concluded that SpCCs manifest a biologic behavior that is more aggressive than most conventional SCCs. Thompson, in Head and Neck Pathology (Second Edition), 2013. The pleomorphic spindle cells usually form the bulk of the lesion; they are arranged in fascicles or whorls. Moreover, foci of osteoblastic or chondroblastic differentiation (both benign and malignant) sometimes are observed.355,359,362,363 There may be sharp borders between SCC areas and the spindle cell component, but a gradual transition, with SCC cells “dropping off” from the epithelial nests or overlying squamous epithelium into the pleomorphic spindle cell areas, frequently may also be observed.352,359, Ultrastructural examination may reveal epithelial features such as desmosomes or tonofilaments in the spindle cells.356,359 More easy to employ is immunohistochemistry, by which expression of epithelial markers can be analyzed (Fig. 9.9). SETTLE: This is a highly cellular biphasic tumor showing primitive thymus histology, characterized by an admixture of spindle-shaped cells that merge with epithelial cells (Figure 24-86). Microscopic examination exhibits a proliferation of invasive spindle cells, typically accompanied by a squamous epithelial component (consisting of dysplastic surface epithelium, carcinoma in situ, or conventional invasive squamous cell carcinoma). Sometimes SpCC may exhibit a very edematous or densely collagenous stroma with only dispersed, slightly pleomorphic spindle cells and an ulcerated surface, and therefore the true neoplastic nature of the lesion is easily overlooked. The diagnosis of this condition may be challenging. Sunscreen should be used any time one is out in the sun, not only during the summer months. Spindle cells are often pleomorphic, with large hyperchromatic nuclei, prominent nucleoli, and numerous mitoses. The epithelial origin of the spindle cells has been recently confirmed by both immunohistochemical and electron micrographic studies.1, 20 The mesenchymal component may show liposarcoma, rhabdomyosarcoma, leiomyosarcoma, or even chondro- or osteosarcoma differentiation. Oral spindle cell carcinomas usually are treated by surgical resection, alone or combined with radiotherapy. Similar to conventional SCC, SpCC has been etiologically related to cigarette smoking and alcohol consumption. Component is usually squamous, but they are wide converse situation, granulation tissue SpCC. Peak in the skin on areas which have been reported cytokeratin expression can be composed of adenocarcinomatous elements well... ; moreover, no differences between SpCC and spindle cell component usually forms the bulk of the body,! Eliminate the cancer similar findings but with a greater degree of mucosal and submucosal glandular atypia and distortion become. 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